In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations.

EC 50 72h values for both AS and DHA showed significant differences among the years ( P < 0.001, one-way ANOVA), but they did not follow a clear trend over the years.

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Together with previous reports documenting delayed parasite clearance, the presence of day-3 positive parasites after ART/ACT treatments, and the high prevalence of K13 polymorphisms in the same border area ( Kyaw et al., 2013 ; Nyunt et al., 2015 ; Wang et al., 2015c ), this study revealed an increasing trend of reduced ART susceptibility in the P. falciparum population at the China-Myanmar border.

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