Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes?

Lu et al., who developed an intracellular-labile amphiphilic CUR-based micelles delivery system (CUR-PEG), observed a highly significant inhibition of tumor growth matched with a strong CTL response and high amounts of IFN-γ when this polyphenol micelles were administered in combination with lipid/calcium/phosphate (LCP) Trp2-based vaccine to treat B16F10 advanced melanoma in C57BL/6 mice [ 95 ].

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The expression of vascular endothelial growth factor (VEGF) was significantly decreased after combined treatment (8 mM MET + 110 μM CUR) and after MET alone, while CUR alone only showed a trend for reduction.

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