The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats.

Although not statistically significant, after 3 weeks of exposure with the low dose of I-BET-151 (2 mg/kg/day), there was a strong trend towards less severe mitochondrial injury as compared to the higher dose, both in the right ( Figure 1 C,c and Table 1 ) and in the left ( Figure 1 I,i and Table 1 ) ventricles.

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Metabolic analyses showed a small trend towards a reduction in mitochondrial respiration in this group ( Figure 4 A).

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