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Cerebrospinal Fluid (CSF) Exchange with Artificial CSF Enriched with Mesenchymal Stem Cell Secretions Ameliorates Experimental Autoimmune Encephalomyelitis.

Int J Mol Sci · 2019 · PMC6480705 · PMID 30978957

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showed a trendp = 0.07so close (0.05 < p ≤ 0.1)
EAE-mice treated with “in/out” enriched-aCSF exchange therapy at days 6–8 following EAE-induction showed a trend towards a lower average clinical EAE-score at days 9–11 post EAE-induction (repeated ANOVA (f(1,16) = 3.73, p = 0.07), with a t -test for day 10 (4 days after starting treatment/2 days following end of treatment) revealing a significant difference in the average clinical score between treated and untreated mice (0 vs. 1.08 ± 0.30, respectively, p = 0.012).

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