Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial.

Clin Infect Dis · 2019 · PMC6481997 · PMID 30188978

Europe PMC DOI

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0.0700

closest p · 1.4× alpha

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The sentences

showed a trendP = .07so close (0.05 < p ≤ 0.1)

Although not statistically significant, children receiving allometric dosing showed a trend ( P = .07) for much more rapid miltefosine accumulation than children on conventional dosing, with median day-7 plasma concentrations of 5.88 μg/mL (range 0.66–14.3 μg/mL) versus 2.67 μg/mL (range 0.70–12.8), respectively.

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