Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT?

Curr Control Trials Cardiovasc Med · 2001 · PMC64825 · PMID 11806808

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did not reach statistical significanceno p-value reported

The Veterans Administration studies in the 1960s proved beyond doubt that treating hypertension with thiazides and β-blockers (the drugs available at that time) significantly diminished the rates of strokes, renal failure, and heart failure, although the decrease in the rate of myocardial infarcts did not reach statistical significance.

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