Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Report of the Intergroup Exemestane Study (IES)-PathIES.

Breast Cancer Res Treat · 2019 · PMC6491661 · PMID 30680659

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a negative trendno p-value reported

Finally, a negative trend was observed between age and pT202/T204MAPK as well as pS118ERα; however, these trends were not statistically significant at 10% false discovery rate: older patients tend to have lower phosphorylation levels of MAPK ( p BH = 0.07) and ERα-S118 ( p BH = 0.07) (Online Resource 8).

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a positive trendno p-value reported

Similarly, a positive trend was found when comparing pT308AKT and pS473AKT (Table 4 ).

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