Whereas quantitative reverse transcriptase PCR (qRT-PCR) analysis in livers of mice fed a CD showed a trend of decreased gene expression related to fatty acid oxidation and secretion in Arid1a LKO mice (Supplementary Fig. 3a-c), the mRNAs encoded by these genes involved in FAO ( Pparα , Cpt1a , Acox1 , Pgc1α , Hmgcs2 , etc.) and secretion ( Mttp ) were significantly reduced in the Arid1a LKO mice with HFD administration.
1
—
—