Time Course of Ischemic and Bleeding Burden in Elderly Patients With Acute Coronary Syndromes Randomized to Low-Dose Prasugrel or Clopidogrel.

In the original analysis, low‐dose prasugrel reduced a composite ischemic end point (cardiovascular death, MI, and stroke) by 21% compared with clopidogrel, a difference that did not reach statistical significance. 18 The discrepancy observed between the original analysis and this one is due to the fact that ADR computation of ischemic burden considers all ischemic complications rather than the first occurring event.

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