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Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.

Biomed Res Int · 2019 · PMC6500679 · PMID 31119153

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JQ1 Reverses the TGF β -Induced Imbalance in NOX4 and SOD2 Expression and Reduces Intracellular ROS Levels and ACTA2 Expression JQ1(+) led to a reduction in NOX4 and ACTA2 mRNA compared to JQ1(-) after 24 h in non-ILD control pulmonary fibroblasts but did not reach statistical significance.

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an increasing trendno p-value reported
SOD2 KD also led to an increasing trend in ACTA2 mRNA expression ( Figure 1(c) ) and cell proliferation ( Figure 1(d) ). 3.3.

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