Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis.

Even though disease-free survival is not statistically significant (log-rank (Mantel-Cox) = 2.325, p = 0.127), there is a clear trend that patients with tumors with low COX-2 immunostaining have longer disease-free survival and those with tumors with high COX-2 immunostaining have shorter disease-free survival ( Figure 3 ). 4.

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