Menopause Early age at menopause (≤40–45 years) was found to be statistically significantly associated ( 182 ) with the subsequent development of rheumatoid factor (RF)-negative RA, whereas it was positively correlated with RF-positive RA, but the association did not reach statistical significance.
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Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan.
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