Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator.

Another study in cholesterol-fed rabbits showed that subcutaneous recombinant tPA inhibited the effect of balloon injury on luminal area compared with controls, but this effect did not reach statistical significance; the potential problem with the delivery method was discussed ( Alexander et al., 2004 ).

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The most novel finding here is the discovery that changes in genes related to nervous system function as well as vascular tone regulation, were highly significant at early time points, suggesting a possible connection between these two pathways leading to early outward vessel remodeling.

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