Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts.

Oncotarget · 2019 · PMC6505631 · PMID 31105871

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did not reach statistical significanceno p-value reported

Co-administration of Aplidin and Btz also decreased CTX levels, however these results did not reach statistical significance (Figure 6C ).

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