A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.

PLoS Pathog · 2019 · PMC6508626 · PMID 31071189

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showed a trendno p-value reported

While several other mutants, most notably Y32A and E334A, also showed a trend towards reduced NS1 –precursor interaction ( Fig 6 and Table 2 ), their impact was much weaker compared to the G161A and W168A substitutions.

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