A tendency for slightly more withdrawals due to AEs was observed with topical ketoprofen compared with placebo, but the OR did not reach statistical significance (OR 1.37, 95% CI 0.99–1.89; I 2 = 0%) (ESM 2).
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Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.
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