Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.

Drugs Aging · 2019 · PMC6509215 · PMID 31073926

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did not reach statistical significanceno p-value reported

placebo (RR 3.39, 95% CI 2.22–5.18; I 2 = 37.1%), and the risk of dry mouth or oral ulceration was also increased with IR opioids (RR 4.43, 95% CI 0.92–21.24; I 2 = 47.5%), although this did not reach statistical significance.

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