A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.

Transl Psychiatry · 2019 · PMC6510753 · PMID 31076569

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highly significantno p-value reported

Moreover, the most highly significant upregulated and downregulated genes affected by the consumption of a HFD are shown (Fig. 2a ).

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a slight trendno p-value reported

did not reach statistical significanceno p-value reported

There was a slight trend, but one that did not reach statistical significance, for increased total PDE4 activity in mice fed an HFD for 3 weeks vs. mice fed an ND (Supplementary Fig.

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