Moreover, these bivalent cis-elements showed a trend toward reduction of H3K4me3 peak intensity in all patients, suggesting a correlation between a prolonged exit from the cell cycle as a consequence of Ibrutinib treatment and demethylation of both H3K27me3 and H3K4me3 at silenced chromatin.
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Ibrutinib induces chromatin reorganisation of chronic lymphocytic leukaemia cells.
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