Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity.

Proc Natl Acad Sci U S A · 2019 · PMC6511047 · PMID 31019077

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did not reach statistical significanceno p-value reported

Anti–CTLA-4 also enhanced the CD8 + to Treg cell ratio in WT and xCT −/− mice, although the increase did not reach statistical significance due to the high intertumoral heterogeneity in the numbers of infiltrating T cells ( Fig. 6 C ).

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