Human Papillomavirus Type 16 Disables the Increased Natural Killer Cells in Early Lesions of the Cervix.

A future work will be focusing on evaluating other candidate cytokines (which in the present study showed a trend of change but with no statistical significance) such as IL-6, GM-CSF, CCL-5, and membrane protein DNAM-1 in HPV infection; (3) in the mixing of specimens for flow cytometry analysis, according to Hubert's study [ 21 ], the number of NK cells in cervical biopsies was too low to score, and they could only be counted in the stroma.

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But despite the viral types, HPV infection induced a decreasing trend of IFN- γ transcription at the cervical surface.

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