Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses.

Front Neurosci · 2019 · PMC6514132 · PMID 31133787

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In studies on a small number of MCI patients, treatment with Posiphen for 10 days reduced in CSF the secreted amino terminal fragments of APP (i.e., sAPPα and sAPPβ), total tau, p-tau, and showed a trend toward reduced Aβ42 ( Maccecchini et al., 2012 ).

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