In comparison with group C, untreated D cells exhibited a significant downregulation of ryanodine receptors (RyR2) ( Figure 2 B) and a decline of the ratio between the phosphorylated and the total form of phospholamban (PLB-P/PLB-TOT, −45%, Figure 2 C), although this last difference did not reach statistical significance ( p = 0.08).
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The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Restores Cardiomyocyte Contractility in a Rat Model of Early Diabetes.
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