Chronic Treatment with Multi-Kinase Inhibitors Causes Differential Toxicities on Skeletal and Cardiac Muscles.

Furthermore, expression of BNP, a marker of cardiac hypertrophy [ 15 , 16 ], was also elevated in the heart of animals exposed to regorafenib (+33%, p < 0.001) and sorafenib (+25%), although in the latter case the difference did not reach statistical significance ( Figure S2 ).

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