A significant increase was also observed in MCI plasma samples for miR-181c-5p ( P = 0.0004, log2 fold change = 0.80) and miR-210-3p ( P = 0.0276, log2 fold change = 0.49) whereas an increasing trend was observed for miR-92a-3p ( P = 0.0798, log2 fold change = 0.55).
As shown in Additional file 1 : Figure S3, we observed a decrease in NPTX1 and NPTXR although it did not reach statistical significance likely due to the low number of samples.
Thus, although there is an overall trend to increase in the hippocampus and entorhinal cortex, it is not possible to conclude that miRNA changes observed in plasma are related to those observed in the brain since they lack global statistical significance. miR-181c-5p has neuronal pentraxin 1 (NPTX1) and neuronal pentraxin receptor (NPTXR) as potential targets.