The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

PLoS Pathog · 2019 · PMC6521996 · PMID 31095648

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did not reach statistical significanceno p-value reported

Viral titers were also increased in cells transfected with siPARP12.2 or with siPARP14.1, although the increased replication of N1347A virus in PARP14 knockdown cells did not reach statistical significance ( Fig 5B ).

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