Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8<sup>+</sup> T-Cell Dysfunction.

Cells · 2019 · PMC6523920 · PMID 31027182

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0.0800

closest p · 1.6× alpha

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a statistical trendp = 0.08so close (0.05 < p ≤ 0.1)

A statistical trend suggested an increase of CD86 + M1 cells in HCV + (F0-2) individuals compared to controls ( p = 0.08), and statistically significant increases in CD86 + M0 and M1 cells in HCV + (F3-4) individuals ( p = 0.03 and 0.02, respectively, Figure 1 c,d) were observed; levels that are more comparable to that of the M2a subset in controls.

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did not reach statistical significanceno p-value reported

The production of pro-inflammatory IFN-γ by putative M1 cells derived from HCV-infected individuals seemed to be reduced (HCV + (F3-4) average 164.0 pg/mL) compared to controls (average 798.5 pg/mL), although this did not reach statistical significance ( Figure 2 c, right panel).

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