Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation.

In the absence of BAMBI, thrombus formation was reduced, as the time at which the first thrombocytes attached (TTA) to the injured vessel wall was significantly delayed and the thrombus size (TSA) was significantly decreased. 4 Similar results were found in the LRRC32 knockdown zebrafish 4 ; although the increase in TTA was only marginally significant compared with controls, the thrombocyte aggregation was clearly impaired in Lrrc32 -downregulated zebrafish after laser-induced thrombosis.

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