Contrary to individual study results, relative change in PRO did not reach statistical significance between groups (SMD -0.26, 95% CI -0.55, 0.05, p = 0.10) (Fig. 3 ) in the meta-analysis; the effect size was also considered small.
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Preoperative opioid use is associated with worse patient outcomes after Total joint arthroplasty: a systematic review and meta-analysis.
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