Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.

Monitoring of retinal morphology by optical coherence tomography (OCT) and retinal thickness measurement did not reveal any significant changes in AAV-Cre mice 1 mo postinjection besides some loss of retinal lamination ( Fig 5A and B ), but scotopic electroretinogram (ERG) recording showed a trend, although nonstatistically significant, toward a reduction of the a - and b -wave amplitudes, whereas the RPE generated c -wave was decreased by ≈66% ( Fig S3C ).

also in 53,322 other papers