Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.

4g, h ), whereas Aβ38 and Aβ40 were significantly increased and Aβ42 levels showed a trend for being elevated, p = 0.1 (Supplementary Fig. 4i , Fig. 4g, h ).

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Conversely, in BACE1-overexpressing cells, Aβ34 levels were significantly elevated approximately threefold compared with APP-overexpressing conditions, whereas Aβ38, Aβ40, and Aβ42 levels showed only a mild trend toward elevation compared with the control (Fig. 3e–h ).

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