Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma.

Strikingly, although with borderline significance, the mutational contribution of signature 12 in the tumors tends to associate with the age at diagnosis (rho = 0.71, p = 0.02).

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Only two out of the 138 prioritized genes were nominally significant in the TCGA-KIRC dataset, namely SIPA1L2 ( p = 0.036), which encodes the signal-induced proliferation-associated 1 like 2, and EIF3A ( p = 0.048), which encodes the eukaryotic translation initiation factor 3 subunit A.

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