a significant trendP < 0.001
The P values are indicated for the lowest dose with a significant effect (indicated by a single asterisk [*]) and curves with a significant trend (indicated by a pound sign [#]). ###, P < 0.001; # or *, P < 0.05.
The P values are indicated for the lowest dose with a significant effect (indicated by a single asterisk [*]) and curves with a significant trend (indicated by a pound sign [#]). ###, P < 0.001; # or *, P < 0.05.
S5A ), we were able to fit dose-response curves to 8 inhibitors (Ro 31-8220 mesylate, D-609, idelalisib, NSC663284, PD98059, SD169, SL327, and wortmannin), among which 1 (Ro 31-8220 mesylate) was cytotoxic and 2 (NSC663284 and SD169) showed a trend toward significance but gave results that were above the level seen with the control (DMSO [dimethyl sulfoxide]).