Effect of rituximab treatment on T and B cell subsets in lymph node biopsies of patients with rheumatoid arthritis.

Increased frequency of follicular B cells in lymph node biopsies of RA patients compared with healthy controls In LN biopsies, the relative frequencies and absolute numbers of CD19 + B cells showed a trend towards an increase in RA patients (median 21% and 22 662 per 100 000 CD45 + cells) compared with HCs (median 11% and 11 597 per 100 000 CD45 + cells, P = 0.15 and P = 0.09, respectively) ( Fig. 1A and Supplementary Fig.

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Based on CD27 and IgD expression there was a numerical trend towards increase in the absolute numbers of unswitched memory (CD27 + IgD + ) B cells (median 4124 per 100 000 CD45 + cells) compared with HCs (median 1421 per 100 000 CD45 + cells, P = 0.13) ( Supplementary Fig.

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