Seasonal variability of vitamin D status in patients with inflammatory bowel disease - A retrospective cohort study.

remission OR 17.8; [95% CI: 4–122]; P = 0.0005) correlated positively with the presence of vitamin D deficiency while the season of patient visit was close to significance (winter/spring vs . summer/fall OR 2.5; [95% CI: 1.0–6.8]; P = 0.05) The associations between vitamin D deficiency and active smoking, history of CD-related operations, mild and severe disease activity did not reach statistical significance ( Fig 3A ).

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Moreover, patients with moderate disease activity had significantly lower corrected absolute 25(OH)D concentrations as compared to patients in remission while the difference for severe activity did not reach statistical significance ( Fig 2 ), which may be influenced by the fact that the number of patients with severe activity was rather limited in this outpatient cohort.

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