Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.

Although there was a trend towards increased MuRF1 expression in cIAP1-infected myotubes, this upregulation did not reach statistical significance (Fig. 2 i, j).

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Interestingly, the loss of cIAP1 did not appear to significantly attenuate denervation-induced atrophy in the soleus muscle, although a slight trend was seen (Fig. 3 a, c).

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