CD8 infiltration by IHC only showed a trend towards improved OS, but CD8A transcript levels were significantly associated with better OS (HR 0.72 (95%CI 0.55–0.95; p = 0.016, Fig 3B ).
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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer.
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