Exploring Sirolimus Pharmacokinetic Variability Using Data Available from the Routine Clinical Care of Renal Transplant Patients - Population Pharmacokinetic Approach.

J Med Biochem · 2019 · PMC6534959 · PMID 31156343

Europe PMC DOI

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quite significantno p-value reported

Change in CL/F between the youngest (16 years) and the oldest patient (64 years) included in this study was approximately 49%.This, quite significant influence of age could be partly attributed to the well-known decline in a number of physiological processes with age.

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