Association of Twice-Daily Radiotherapy With Subsequent Brain Metastases in Adults With Small Cell Lung Cancer.

For patients with late prophylactic cranial irradiation, the rates of brain metastasis tended to be higher in the TDRT group but marginally significant (HR, 1.81; 95% CI, 0.99-3.31; P = .05), and the rates of brain metastasis were not significantly different among those who received early prophylactic cranial irradiation (HR, 1.39; 95% CI, 0.49-3.99; P = .54).

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Patients treated with TDRT showed a trend of higher, but marginally significant, risks of developing brain metastases when adjusting by the timing of prophylactic cranial irradiation (HR, 1.71; 95% CI, 1.01-2.89; P = .05) (eTable 7 in the Supplement ).

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