The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine.

NPJ Vaccines · 2019 · PMC6538625 · PMID 31149350

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showed a trendno p-value reported

16 – 18 In agreement with this, immunizations that produced the highest CfaEB-specific IgA and IgG2a responses showed a trend towards producing the greatest CFA/I-specific HAI titers.

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highly significantno p-value reported

In fact, prior exposure to ETEC may provide highly significant protection against reinfection with the homologous strain or with an ETEC strain expressing the same or related CFs as demonstrated in animal models and in human volunteers. 4 , 5 Moreover, the cholera vaccine Dukoral ® (Valneva) provides short-term protection against LT-expressing ETEC by elicitin

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.