showed a trendp = 0.066
Unhabituated animals injected with 1 mg/kg of CNO showed a trend toward reduced RR (−12.88%, p = 0.066) and significantly reduced V T (−16.52%, p = 0.00085) and V̇ E (−28.08%, p = 0.0070), leading to an overall reduction in V̇ E / V̇ O2 (−22.23%, p = 0.016) ( Figure 3 ).