Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites.

While the data confirm that CSP is one of the major antigens recognized by malaria-immune B cells, they also show that other sporozoite-specific antigens are present and recognized by a significantly higher number of B cells; (b) the frequency of CSP-specific B cells is significantly higher in subjects protected by the RAS vaccine (p = 0.016, 2-sided T-test); (c) the frequency of sporozoite-specific B cells has a strong trend to be higher in protected subjects (p = 0.08, 2-sided T-test).

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