The CANVAS Program: implications of canagliflozin on reducing cardiovascular risk in patients with type 2 diabetes mellitus.

Although results for the composite of CV death or hospitalization for HF were consistent between different subgroups, the presence of a baseline history of HF presented a borderline significant interaction, suggesting that perhaps the benefits of canagliflozin may be greater in those with a history of HF compared to those without [ 42 ].

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Effect estimates suggest a benefit with canagliflozin treatment on all 3 components of the primary composite outcome compared with placebo (CV death [11.6 vs 12.8 per 1000 patient-years], nonfatal MI [9.7 vs 11.6 per 1000 patient-years], and nonfatal stroke [7.1 vs 8.4 per 1000 patient-years]), though individual effects did not reach statistical significance [ 16 ].

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