Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts.

In the case of BJ-hTERT fibroblasts, 1,25(OH) 2 D 3 also significantly reduced cell migration while Wnt3A showed a tendency that did not reach statistical significance ( P = 0.073) (Fig. 5e ).

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Second, a highly significant direct correlation existed between the observed experimental effect of the combined treatment (log 2 of the fold-change vs . vehicle-treated cells) and the theoretically expected additive effect (calculated by the sum of the log 2 of the fold-change vs . vehicle-treated cells of the single treatments) for all the genes differentially expressed by the single treatments (Fig. 1d ), and specifically for the 800 genes that were common targets of the single treatments (Fig. 1e ).

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