Effectiveness over time of a multimodal intervention to improve compliance with standard hygiene precautions in an intensive care unit of a large teaching hospital.

In the join-point regression analysis, a significant trend variation (MPC: 6.46, p < 0.001) in the overall compliance rate was apparent over the first 11 months, while the last 7-month period showed a non-significant variation (MPC: − 2.10, p = 0.1) [Fig. 1 B].

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