p38α MAPK inhibition translates to cell cycle re-entry of neonatal rat ventricular cardiomyocytes and de novo nestin expression in response to thrombin and after apex resection.

Sci Rep · 2019 · PMC6547723 · PMID 31160695

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0.0800

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did not reach statistical significancep = 0,08so close (0.05 < p ≤ 0.1)

p38α/β MAPK inhibitor SB203580 (5 mg/kg) administered immediately after apex resection and continued for two additional days reduced the overall fibrin clot region (0,509 ± 0,083 mm 2 ; n = 6) but did not reach statistical significance (p = 0,08) versus vehicle-treated apex-resected neonatal rats (0,812 ± 0,141 mm 2 ; n = 5) (Figs 5 and 6C ).

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