A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants.

4 × 10 −4 ) and highly significant (median predictor cross-validation P = 4.6 × 10 −4 ), consistent with previous findings that low average heritability of gene expression can be compensated for by sample size sufficient to produce reliable genetic predictors ( Supplementary Table 7 ).

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82/106 associated models were significantly correlated with expression/splicing measured in at least one independent cohort (after Bonferroni correction for 388 model-by-cohort pairs tested, with 92/106 nominally significant after Bonferroni correction for 4 cohorts tested).

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