Vascular defects of <i>DYRK1A</i> knockouts are ameliorated by modulating calcium signaling in zebrafish.

Consistent with these findings, dantrolene, a RyR antagonist that decreases the intracellular calcium level ( Fruen et al., 1997 ), was also identified as a modestly effective small molecule in our chemical screening, although it did not reach statistical significance in our detailed analyses ( Table S3 and data not shown).

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