Despite the high negative correlation between HDL and very low-density lipoprotein (VLDL) or low-density lipoprotein (LDL) measures, only a few associations with LDL or VLDL measures were found nominally significant and none remained significant after correction for multiple comparisons.
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Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine.
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Other HDL particle measures (XL-HDL–[C, CE, FC, L, P, and PL], L-HDL–[C, CE, FC, L, P, PL, and TG], total cholesterol in HDL and HDL2, the mean diameter for HDL particles, and the total cholesterol to total lipids ratio in very large HDL) were also reduced in migraine, but failed to reach significance after correction for multiple comparisons (table e-4; doi.org/10.5061/dryad.p698mn7 ).