Identification of potential biomarkers of vaccine inflammation in mice.

The TLR3 agonist Poly I:C invoked an SAA3 expression profile in which the molecule reached 33.11 μg/mL at 4 hr before falling back to 15.04 μg/mL at 8 hr and rising again to 33.54 μg/mL at 24 hr, although these differences did not reach statistical significance when compared to the saline control.

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When graphed in a volcano plot, showing the highly significant fold-change differential expression of the proteins, it is clear that groups of cyto/chemokines and SAA3 allow us to differentiate specific signatures for each individual vaccine condition.

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